On January 4th 1951, after five years of renovation works, the company’s brand new modern and white building finally open its doors. Among the special guests attending the opening ceremony, there’s Giulio Natta, Franco Dompé’s former university professor, who will win the Nobel Prize for Chemistry 10 years later. With a rationalist architecture, the renovated headquarters of Dompé farmaceutici are particularly ahead of time for their innovative machineries, addressed to the production of medicines in vials.

Laboratori 51 - fiale

Thanks to this avant-garde technology, hosted in a 15.000 m2 production plant, Dompé will come up with many successful drugs, first and foremost two new ways (intravenous and intramuscular) to administer the anti-cough drug Guaiacalcium. This product is the perfected version of Creosotina, a drug based on beech wood creosote that Franco’s father, Onorato Dompé, had developed to fight chest-related illnesses. With the launch of Guaiacalcium in the Post-War years, the company scales up its production to an industrial level, focusing on the treatment of respiratory infections.

Guaiacalcium tipologie


The catalogue of Guaiacalcium grows in the following years, with the development of new formulations (C, S and Efedrina) and ways of administration (intravenous, intramuscular, nebulizer, suppository, and syrup). The most popular one, is Guaiacalcium syrup, which the ads of the time describe as a medical punch with a lovely taste («punch medicinale di gusto squisito»).

Guaiacalcium sciroppo - punch medicinale

Clearly not according to everyone if, in a memorable scene of Ieri, Oggi, Domani, the Oscar-winning movie by Vittorio De Sica, Sophia Loren has some troubles in giving to her child the company’s popular antitussive.

Sophia Loren


Despite Guaiacalcium’s success, Franco decides to further perfect the formulation of the drug, launching in 1983, Fluifort.